Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer
Matteo Bellone, Arianna Brevi, Samuel Huber
Abstract
Technologies allowing genetic sequencing of the human microbiome are opening new realms to discovery. The host microbiota substantially impacts immune responses both in immune-mediated inflammatory diseases (IMIDs) and in tumors affecting tissues beyond skin and mucosae. However, a mechanistic link between host microbiota and cancer or IMIDs has not been well established. Here, we propose T helper 17 (T H 17) lymphocytes as the connecting factor between host microbiota and rheumatoid or psoriatic arthritides, multiple sclerosis, breast or ovarian cancer, and multiple myeloma.
Topics & Concepts
BiologyImmune systemMicrobiomeImmunologyCancerOvarian cancerPsoriasisMultiple myelomaMultiple sclerosisBioinformaticsGeneticsCancer Immunotherapy and BiomarkersT-cell and B-cell ImmunologyInflammatory Bowel Disease