Long non-coding RNA HOXA11-AS upregulates Cyclin D2 to inhibit apoptosis and promote cell cycle progression in nephroblastoma by recruiting forkhead box P2.
Shibo Zhu, Jingqi Zhang, Yanhong Cui, Xiangliang Tang, Xiaofeng Gao, Dian Li, Wei Jia
Abstract
. Taken together, silencing of HOXA11-AS promotes apoptosis and inhibits the cell cycle entry in nephroblastoma by recruiting the transcription factor FOXP2 to downregulate the expression of CCND2, highlighting a promising novel direction for future nephroblastoma treatment.
Topics & Concepts
Cell cycleCancer researchGene silencingTranscription factorCyclin E1BiologyCyclin D2Long non-coding RNACell growthCell cycle checkpointCyclin D1Downregulation and upregulationApoptosisCell biologyGeneGeneticsRenal and related cancers