PiRNA-4447944 promotes castration-resistant growth and metastasis of prostate cancer by inhibiting NEFH expression through forming the piRNA-4447944-PIWIL2-NEFH complex
Qiang Peng, Yu Chen, Tingting Xie, Dandan Pu, Vincy Wing-Sze Ho, Jingkai Sun, Kang Liu, Ronald Chan, Xiaofan Ding, Jeremy Yuen‐Chun Teoh, Xin Wei Wang, Peter Ka‐Fung Chiu, Chi‐Fai Ng
Abstract
migration and invasion of PCa cells, and reduced cell apoptosis. Mechanistically, piR-4447944 bound to PIWIL2 to form a piR-4447944/PIWIL2 complex and inhibited tumor suppressor NEFH through direct interaction at the post-transcriptional level. Collectively, our study indicates that piR-4447944 is essential for prostate tumor-propagating cells and mediates androgen-independent growth of PCa, which extends current understanding of piRNAs in cancer biology and provides a potential approach for CRPC treatment.
Topics & Concepts
Piwi-interacting RNAProstate cancerMetastasisCancer researchBiologyCancerProstateMedicineBioinformaticsRNA interferenceRNAGeneticsGeneRNA modifications and cancer