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Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19

Keiichi Mitsuyama, Kozo Tsuruta, Hidetoshi Takedatsu, Shinichiro Yoshioka, Masaru Morita, M Niwa, Satoshi Matsumoto

2020Journal of Clinical Medicine25 citationsDOIOpen Access PDF

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route for virus transmission, most likely due to the presence of angiotensin-converting enzyme 2. Therefore, understanding the mechanisms of GI injury is crucial for a harmonized therapeutic strategy against COVID-19. This review summarizes the current evidence for the clinical features of and possible pathogenic mechanisms leading to GI injury in COVID-19.

Topics & Concepts

MedicineCoronavirus disease 2019 (COVID-19)CoronavirusOutbreakGastrointestinal tractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Respiratory tract2019-20 coronavirus outbreakVirusDiseaseTransmission (telecommunications)Angiotensin-converting enzyme 2Respiratory systemVirologyImmunologyInternal medicineInfectious disease (medical specialty)Electrical engineeringEngineeringCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19SARS-CoV-2 and COVID-19 Research
Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19 | Litcius