Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization
Chenfei Wang, Xiaobei Huang, Litao Sun, Qiuxia Li, Zhili Li, Haiyang Yong, Delu Che, Cong Yan, Songmei Geng, Wenxin Wang, Dezhong Zhou
Abstract
sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts.
Topics & Concepts
TransfectionCationic polymerizationGene deliveryChemistryMichael reactionPolymerClosure (psychology)GeneCombinatorial chemistryPolymer chemistryOrganic chemistryBiochemistryCatalysisEconomicsMarket economyRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesBiopolymer Synthesis and Applications