Reductive electrophilic C–H alkylation of quinolines by a reusable iridium nanocatalyst
Rong Xie, Wenhui Mao, Huanhuan Jia, Jialu Sun, Guangpeng Lu, Huanfeng Jiang, Min Zhang
Abstract
), we describe its application in reductive electrophilic mono and dialkylations of quinolines with various 2- or 4-functionalized aryl carbonyls or benzyl alcohols by utilizing renewable formic acid as the reductant. This catalytic transformation offers a practical platform for direct access to a vast range of alkyl THQs, proceeding with excellent step and atom-efficiency, good substrate scope and functional group tolerance, a reusable catalyst and abundantly available feedstocks, and generation of water and carbon dioxide as by-products. The work opens a door to further develop more useful organic transformations under heterogeneous reductive catalysis.
Topics & Concepts
ElectrophileChemoselectivityCatalysisIridiumCombinatorial chemistryChemistryArylFunctional groupAlkylationFormic acidAlkylUmpolungSubstrate (aquarium)Organic chemistryNucleophilePolymerGeologyOceanographyAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsNanomaterials for catalytic reactions