Zwitterionic nanoparticles for thermally activated drug delivery in hyperthermia cancer treatment
Camillo Colli, Ilenia Masi, Emanuela Jacchetti, Silvia Santoni, Mattia Sponchioni, Bianca Maria Colosimo, Laura Rosanò, Manuela Teresa Raimondi, Emanuele Mauri, Davide Moscatelli
Abstract
of NPs to match the therapeutic needs of hyperthermia treatments at 43 °C and tested the nanocarriers in the controlled delivery of paclitaxel, a common anticancer drug. The NPs released almost entirely the encapsulated drug only following 1 h incubation at 43 °C, whereas they retained more than 95% of the payload in the physiological environment (37 °C), thus demonstrating their efficacy as on-demand drug delivery systems. The administration of drug-loaded NPs to ovarian cancer cells led to therapeutic effects outperforming the conventional administration of non-encapsulated paclitaxel, which highlights the potential of the zwitterionic UCST-type NPs as an innovative hyperthermia-responsive drug delivery system.