Accelerating bone regeneration in cranial defects using an injectable organic–inorganic composite hydrogel
Qiao Bian, Chao Guo, Shuquan Cui, Jia Liu, Guohua Xu, Wei Feng
Abstract
drug release experiments demonstrated a gentle and sustained release of SIM for as long as 2 months, benefitting bone regeneration. The excellent capacity of promoting the formation of osteocytes was proved by cell differentiation assays. Furthermore, the enhanced bone regeneration capacity was verified by the micro-CT results of rat cranial defects with implantation time. Based on our results, the organic-inorganic composite integrates the advantages of each component and is far beyond, thus it might serve as a promising material candidate for bone regeneration.
Topics & Concepts
Regeneration (biology)Composite numberMaterials scienceCranial boneBiomedical engineeringComposite materialNanotechnologyMedicineAnatomyCell biologySkullBiologyBone Tissue Engineering MaterialsGraphene and Nanomaterials ApplicationsDental Implant Techniques and Outcomes