Glutathione-sensitive mesoporous nanoparticles loaded with cinnamaldehyde for chemodynamic and immunological therapy of cancer
Lichong Zhu, Wenyue Li, Chuang Liu, Saisai Yue, Yuanyuan Qiao, Yingying Cui, Junwei Cheng, Ming Zhang, Peisen Zhang, Beibei Zhang, Yi Hou
Abstract
We proposed a GSH-responsive mesoporous organosilica nanoparticles-based nanomedicine that can target tumor mitochondria. The nanomedicine can induce apoptosis and immunogenic death of tumor cells, realizing the chemodynamic and immunological therapy of cancer.
Topics & Concepts
NanomedicineCancer therapyGlutathioneApoptosisCancerCancer cellNanoparticleCancer researchMaterials scienceNanotechnologyChemistryMedicineBiochemistryInternal medicineEnzymeNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryCancer Research and Treatments