The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma
Martin Johnson, J. Cory Benson, Trayambak Pathak, Ping Xin, Abagail McKernan, Scott M. Emrich, Ryan E. Yoast, Vonn Walter, Adam C. Straub, Mohamed Trebak
Abstract
/calmodulin-dependent kinase II, and transcriptional and metabolic reprogramming. Using small animal respiratory mechanic measurements and immunohistochemistry, we show that smooth muscle-specific NCLX KO mice are protected against AR, fibrosis, and hyperresponsiveness in an experimental model of asthma. Our findings support NCLX as a potential therapeutic target in the treatment of asthma.
Topics & Concepts
Airway hyperresponsivenessAirwaySodium-calcium exchangerAsthmaCalciumMedicineSodiumChemistryInternal medicineAnesthesiaOrganic chemistryIon Transport and Channel RegulationIon channel regulation and functionIon Channels and Receptors