The Role of Fusobacterium nucleatum in Colorectal Cancer Cell Proliferation and Migration
Zihong Wu, Qiong Ma, Ying Guo, Fengming You
Abstract
Colorectal cancer (CRC) is a common cancer worldwide with poor prognosis. The presence of Fusobacterium nucleatum (Fn) in the intestinal mucosa is associated with the progression of CRC. In this review, we explore the mechanisms by which Fn contributes to proliferation and migration of CRC cells from the following four aspects: induction of the epithelial–mesenchymal transition (EMT), regulation of the tumor microenvironment (TME), expression of oncogenic noncoding RNAs, and DNA damage. This review outlines the scientific basis for the use of Fn as a biomarker and therapeutic target in CRC.
Topics & Concepts
Fusobacterium nucleatumColorectal cancerFusobacteriumCancer researchCancerMedicineCell growthMicrobiologyBiologyInternal medicineBacteriaGeneticsBacteroidesPorphyromonas gingivalisPeriodontitisGut microbiota and healthBerberine and alkaloids researchAnorectal Disease Treatments and Outcomes