Formicamycin biosynthesis involves a unique reductive ring contraction
Zhiwei Qin, Rebecca Devine, Thomas Booth, Elliot H. E. Farrar, Matthew N. Grayson, Matthew I. Hutchings, Barrie Wilkinson
Abstract
cross feeding and biomimetic semi-synthesis experiments we showed that these lactone products represent biosynthetic intermediates that are reduced to formicamycins in a unique reductive ring contraction reaction catalyzed by ForY.
Topics & Concepts
Contraction (grammar)BiosynthesisChemistryRing (chemistry)StereochemistryBiochemistryBiologyEndocrinologyOrganic chemistryGeneMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic StudiesRNA and protein synthesis mechanisms