Iodine‐Mediated Three‐Component Strategy to Synthesize 2‐Aminothiazoles from β‐Diketones/β‐ketoesters, Arylamines and Ammonium Thiocyanate
Abigail Philips, Ajithkumar Arumugam, Yuvaprabhu Eswaramoorthy, Siva Senthil Kumar Boominathan, Gopal Chandru Senadi
Abstract
Abstract A one‐pot, three‐component protocol for the synthesis of 2‐aminothiazoles promoted by iodine from readily available starting materials such as β‐diketones/β‐ketoesters, arylamines, and NH 4 SCN has been developed. A wide range of arylamines was tolerated well to produce the expected polysubstituted 2‐aminothiazoles in moderate to good yields. The characteristic features of this methodology include operational ease, metal‐free reaction conditions, gram‐scale scalability, functional group tolerance, and short reaction times.
Topics & Concepts
ChemistryIodineAmmonium thiocyanateThiocyanateCombinatorial chemistryReaction conditionsAmmonium acetateOrganic chemistryCatalysisHigh-performance liquid chromatographyMulticomponent Synthesis of HeterocyclesSynthesis and biological activityClick Chemistry and Applications