The mechanosensitive Piezo1 channel controls endosome trafficking for an efficient cytokinetic abscission
Julia Carrillo-García, Víctor Herrera-Fernández, Selma A. Serra, Fanny Rubio-Moscardó, Marina Vogel-González, Pau Doñate‐Macian, Covadonga F. Hevia, Cristina Pujades, Miguel A. Valverde
Abstract
signals and ALIX delivery to the ICB, where ALIX recruits the ESCRT-III component charged multivesicular body protein 4B, which promotes abscission. These results provide a different view of how mechanical forces participate in cytokinesis and identify Piezo1 as a key modulator of endosome trafficking.
Topics & Concepts
ESCRTCytokinesisCell biologyEndosomeMechanosensitive channelsPIEZO1MicrotubuleAbscissionMidbodyTSG101BiologyCell divisionChemistryIntracellularCellMicrovesiclesIon channelGeneticsGeneReceptormicroRNAErythrocyte Function and PathophysiologyBlood properties and coagulationCellular Mechanics and Interactions