Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression
Lin Zhao, Yingli Yu, Li Li, Jiarui Wang, Jing Wang, Shijia Su, Jingyi Ding, Yue Zhang, Anhong Wang, Kun Zhou
Topics & Concepts
Protein kinase BReactive oxygen speciesOxidative stressApoptosisViability assayCell biologyMitochondrionMitochondrial ROSMTT assayWestern blotCytotoxicityPhosphorylationOxidative phosphorylationChemistryBiologyFlow cytometryMolecular biologyBiochemistryIn vitroGeneBioactive natural compoundsSirtuins and Resveratrol in MedicineCell death mechanisms and regulation