Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis
José Carlos Rodrigues Nascimento, Lianna Cavalcante Pereira, Juliana Magalhães da Cunha Rêgo, Ronaldo Pereira Dias, Paulo Goberlânio B Silva, Silvio Alencar C Sobrinho, Gustavo Coelho, Ivelise Regina Canito Brasil, Edmilson Ferreira de Oliveira-Filho, James S. Owen, Pierluigi Toniutto, Reinaldo B. Oriá
Abstract
BACKGROUND: polymorphisms may influence HCV-induced liver damage. AIM: alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation (OLT). METHODS: polymorphisms were analyzed by quantitative real-time polymerase chain reaction. RESULTS: = 0.006). CONCLUSION: Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients.