Epidemiology and biology of early onset colorectal cancer
Anand Venugopal, John M. Carethers
Abstract
somatic mutation, compared to loCRC. Other findings include LINE-1 hypomethylation, absence of microsatellite instability (MSI-H), presence of chromosomal instability (CIN) or microsatellite and chromosomal stability (MACS). These studies are only now emerging and have not yet identified a specific molecular signature defining eoCRC. Further research evaluating genetic and molecular differences as well as environmental triggers for eoCRCs should provide a clearer understanding to inform targeted screening for pre-symptomatic at-risk younger individuals.
Topics & Concepts
Microsatellite instabilityColorectal cancerKRASMedicineIncidence (geometry)EpidemiologyCancerDiseaseInternal medicineOncologyAge of onsetBioinformaticsBiologyGeneticsMicrosatelliteAlleleGeneOpticsPhysicsColorectal Cancer Screening and DetectionGenetic factors in colorectal cancerGastric Cancer Management and Outcomes