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An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2

Katherine C. Barnett, Yuying Xie, Takanori Asakura, Dingka Song, Kaixin Liang, Sharon Taft-Benz, Haitao Guo, Shuangshuang Yang, Kenichi Okuda, Rodney C. Gilmore, Jennifer F. Loome, Thomas H. Oguin, Gregory D. Sempowski, Scott H. Randell, Mark T. Heise, Yu L. Lei, Richard C. Boucher, Jenny P.‐Y. Ting

2022Cell Host & Microbe72 citationsDOIOpen Access PDF

Topics & Concepts

InflammasomeBiologyAIM2Immune systemSecretionImmunologyCytokinePyroptosisInnate immune systemInflammationTLR2Caspase 1Respiratory epitheliumCell biologyEpitheliumGeneticsBiochemistryInflammasome and immune disordersCOVID-19 Clinical Research Studiesinterferon and immune responses
An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2 | Litcius