Palladium-Catalyzed Intermolecular Heck-Type Dearomative [4 + 2] Annulation of 2<i>H</i>-Isoindole Derivatives with Internal Alkynes
Tengfei Yao, Fang Zhang, Junliang Zhang, Lu Liu
Abstract
Here, an interesting palladium-catalyzed intermolecular Heck-type dearomative [4 + 2] annulation of 2H-isoindole derivatives with internal alkynes has been developed, affording diverse polycyclic pyrrolidine scaffolds in good yield. This reaction is a useful method for the transformation of 2H-isoindole.
Topics & Concepts
IsoindoleChemistryAnnulationIntermolecular forcePalladiumCatalysisPyrrolidineYield (engineering)Organic chemistryHeck reactionCombinatorial chemistryMedicinal chemistryMoleculeMetallurgyMaterials scienceCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis and pharmacology of benzodiazepine derivatives