Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation
Mengmeng Jiang, Ren Guo, Yan Ai, Gang Wang, Peilan Tang, Xiaohui Jia, Bingqing He, Qianting Yuan, Xin Xie
Abstract
Background & Aims: and find a way to promote the growth of transplanted hepatocytes. Methods: effects of these compounds on transplanted hepatocytes were then evaluated. Results: , by facilitating HPC conversion. Conclusions: and may facilitate the application of hepatocyte therapy. Impact and implications: and may facilitate the application of hepatocyte therapy.
Topics & Concepts
HepatocyteIn vivoTransplantationLiver regenerationCell biologyCancer researchWnt signaling pathwayBiologyIn vitroProgenitor cellStem cellRegeneration (biology)PharmacologyImmunologyChemistryMedicineInternal medicineSignal transductionBiochemistryGeneticsLiver physiology and pathologyOrgan Transplantation Techniques and OutcomesPancreatic function and diabetes