Comprehensive Analyses Reveal Effects on Tumor Immune Infiltration and Immunotherapy Response of APOBEC Mutagenesis and Its Molecular Mechanisms in Esophageal Squamous Cell Carcinoma
Jie Yang, Tao Xiang, Shihao Zhu, Yueqiong Lao, Yuqian Wang, Tianyuan Liu, Kai Li, Yuling Ma, Ce Zhong, Shaosen Zhang, Wen Tan, Dongxin Lin, Chen Wu
Abstract
is associated with immunotherapy response which is predicted by TIDE algorithm, validated in a clinical cohort and further confirmed in mouse models. These findings systematically elucidate the clinical relevance, immunological characteristics, prognostic value for immunotherapy and underlying mechanisms of APOBEC mutagenesis in ESCC, which demonstrate great potential in clinical utility to facilitate clinical decisions.
Topics & Concepts
APOBECMutagenesisImmune systemImmunotherapyBiologyCancer researchInnate immune systemMutationImmunologyGeneGeneticsGenomeRNA modifications and cancerCancer Immunotherapy and BiomarkersImmune cells in cancer