Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis
Yan Jiang, Chan Xiang, Fan Zhong, Yang Zhang, Liyan Wang, Yuanyuan Zhao, Jiucun Wang, Chen Ding, Jin Li, Fuchu He, Haijian Wang
Abstract
EZH2 and JMJD3 antagonistically modulate HSCs activation. The therapeutic effects of DZNep as epigenetic drug in liver fibrosis are associated with the regulation of EZH2 towards direct target genes encoding TGF-β1 pseudoreceptor BAMBI, anti-inflammatory cytokine IL10 and cell cycle regulators CDKN1A, GADD45A and GADD45B, which are also regulated by JMJD3. Our present study provides new mechanistic insight into the epigenetic modulation of EZH2 and JMJD3 in HSCs biology and hepatic fibrogenesis.
Topics & Concepts
EZH2Hepatic stellate cellDemethylaseMethyltransferaseLiver fibrosisCancer researchChemistryHistoneHistone methyltransferaseHepatic fibrosisHistone methylationFibrosisCell biologyInternal medicineMethylationMedicineBiologyBiochemistryDNA methylationGene expressionGeneLiver Disease Diagnosis and TreatmentLiver physiology and pathologyEpigenetics and DNA Methylation