Evaluation of Oxidative Stress Parameters and Antioxidant Status in Coronary Artery Disease Patients.
Sowmya Varadhan, R Venkatachalam, S M Perumal, S S Ayyamkulamkara
Abstract
<0.05). Total cholesterol, triglyceride, and LDL were significantly high in CAD patients. A significant negative correlation was observed between MPO and PON levels and between MDA and GSH levels. Increased oxidative stress and decreased antioxidant status were observed in patients with CAD. Formation of oxLDL increased MPO and decreased PON are all additional risk factors for the development of CAD and can be targeted for future therapeutic purposes. Lifestyle modifications and treatment methods can reduce CAD risk through the reduction of oxidative stress and improvement of antioxidant status.
Topics & Concepts
Oxidative stressMyeloperoxidaseCoronary artery diseaseMalondialdehydeParaoxonaseAntioxidantTriglycerideGlutathioneInternal medicineMedicineContext (archaeology)Lipid peroxidationLipoproteinGastroenterologyEndocrinologyImmunologyChemistryCholesterolInflammationBiochemistryEnzymeBiologyPaleontologyParaoxonase enzyme and polymorphismsMedical and Biological Ozone ResearchApelin-related biomedical research