RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus
Jodie A. Schildkraut, Jordy P. M. Coolen, Sophie Burbaud, Jasper J. N. Sangen, Michael P. Kwint, R. Andres Floto, Huub J. M. op den Camp, Lindsey H. M. te Brake, Heiman F. L. Wertheim, Kornelia Neveling, Wouter Hoefsloot, Jakko van Ingen
Abstract
Mycobacterium abscessus is an opportunistic pathogen notorious for its resistance to most classes of antibiotics and low cure rates. M. abscessus carries an array of mostly unexplored defense mechanisms. A deeper understanding of antibiotic resistance and tolerance mechanisms is pivotal in development of targeted therapeutic regimens.
Topics & Concepts
Mycobacterium abscessusMicrobiologyBiologyRegulonTranscriptomeAmikacinAntibioticsAntibiotic resistanceMultidrug toleranceClofazimineKanamycinAcinetobacter baumanniiAntibacterial agentPolymyxin BMycobacteriumSigma factorResistomeTigecyclineBacterial geneticsBacteriaSmall RNAMycobacterium research and diagnosisTuberculosis Research and EpidemiologyQuinazolinone synthesis and applications