Pd/β-cyclodextrin-catalyzed C–H functionalization in water: a greener approach to regioselective arylation of (NH)-indoles with aryl bromides
Peng Xu, Xin Hong Duan
Abstract
A greener and more practical approach to the regioselective C3/C2-arylation of (NH)-indoles with (hetero)aryl bromides in water is developed via the Na 2 PdC l4 -catalyzed and β-cyclodextrin ligand-mediated cross-coupling reactions.
Topics & Concepts
ChemistryRegioselectivityArylCyclodextrinCatalysisSurface modificationLigand (biochemistry)Combinatorial chemistryOrganic chemistryMedicinal chemistryPhysical chemistryAlkylBiochemistryReceptorCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsNanomaterials for catalytic reactions