Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine–Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors
Heba T. Abdel‐Mohsen, Ahmed M. El Kerdawy, Mohamed A. Omar, Andrea Petreni, Rasha M. Allam, Hoda I. El Diwani, Claudiu T. Supuran
Topics & Concepts
ChemistryCarbonic anhydraseAcetazolamidePotencyMoietySelectivityStereochemistryEnzymeIC50Gene isoformBiochemistryIn vitroGeneInternal medicineCatalysisMedicineEnzyme function and inhibitionSynthesis and Catalytic ReactionsCholinesterase and Neurodegenerative Diseases