Litcius/Paper detail

Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine–Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors

Heba T. Abdel‐Mohsen, Ahmed M. El Kerdawy, Mohamed A. Omar, Andrea Petreni, Rasha M. Allam, Hoda I. El Diwani, Claudiu T. Supuran

2021European Journal of Medicinal Chemistry50 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryCarbonic anhydraseAcetazolamidePotencyMoietySelectivityStereochemistryEnzymeIC50Gene isoformBiochemistryIn vitroGeneInternal medicineCatalysisMedicineEnzyme function and inhibitionSynthesis and Catalytic ReactionsCholinesterase and Neurodegenerative Diseases