Metal–Organic Framework-Based Self-Powered Chemodynamic Therapy Nanosystem: CaO<sub>2</sub>@PCN-222(Fe) and Its Mixed Matrix Membranes for Promoting Infected Wound Healing
Han-Xiao Feng, Xiaodong Su, Dahai Hu, Yi-Fei Hui, Hongxin Su, Jilin Jiang, Ruyi Ji, Shulin Li, Zu‐Jin Lin, Faqiang Tang
Abstract
Bacterial infections pose an increasing threat to human health. Chemodynamic therapy (CDT), which utilizes nanozymes to catalyze H 2 O 2 into highly toxic hydroxyl radicals (·OH), offers a promising disinfection strategy because of its high efficacy, broad-spectrum antibacterial activity, and low risk of inducing drug resistance. Herein, we developed a self-powered CDT nanocomposite, CaO 2 @PCN-222(Fe), via a facile one-pot synthesis for wound disinfection. In infected wounds, the CaO 2 component of the composite gradually hydrolyzes to H 2 O 2, while the PCN-222(Fe) component acts as peroxidase mimics to efficiently catalyze the generated H 2 O 2 into ·OH, thus achieving self-powered CDT. In vitro assays confirmed that the minimum bactericidal concentration of the composite against Staphylococcus aureus is as low as 31.25 μg mL –1 . Furthermore, in vivo assays demonstrated that the composite could effectively accelerate infected wound healing. To broaden application scenarios, the composite was further integrated into poly(vinylidene fluoride) (PVDF) to form CaO 2 @PCN-222(Fe)@PVDF mixed matrix membranes (MMMs), which inherit the self-powered CDT capability, exhibiting high antimicrobial activity and promoting infected wound healing. Notably, no significant toxicity was observed for CaO 2 @PCN-222(Fe) and its MMMs. This work presents an efficient self-powered CDT modality, combining the advantages of CaO 2 and peroxidase mimics for treating bacterial infections and promoting infected wound healing.