Prevention of Corneal Myofibroblastic Differentiation <i>In Vitro</i> Using a Biomimetic ECM Hydrogel for Corneal Tissue Regeneration
Shibu Chameettachal, Deeksha Prasad, Yash Parekh, Sayan Basu, Vivek Singh, Kiran Kumar Bokara, Falguni Pati
Abstract
and prevents their transdifferentiation to myofibroblasts. From the above results, it is evident that dCMH maintains the keratocytes with the ability to regenerate the corneal defect without scar. We thus suggest a simple yet effective approach for corneal tissue decellularization and that dCMH can be a promising material for prophylaxis against blinding scar formation in an injured cornea.
Topics & Concepts
DecellularizationRegeneration (biology)CorneaMyofibroblastTransdifferentiationExtracellular matrixCadaveric spasmMedicinePathologyTissue engineeringOphthalmologyCell biologyBiomedical engineeringAnatomyBiologyStem cellFibrosisCorneal Surgery and TreatmentsTissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical Applications