New Cocrystal of Ubiquinol with High Stability to Oxidation
Lídia Bofill, Dafne de Sande, Rafael Barbas, Rafel Prohens
Abstract
A new cocrystal of the essential nutrient ubiquinol that is highly resistant to air oxidation has been designed and discovered in a cocrystal screening. Hydroxybenzoic acids and phenols have been selected as the coformers with the aim to transfer their molecular antioxidant properties to the cocrystal and protect ubiquinol from oxidation. The new cocrystal ubiquinol/3,4-dihydroxybenzoic acid shows a remarkably high stability under standard stress conditions, which offers alternative strategies of formulation for an important industrial problem.
Topics & Concepts
CocrystalUbiquinolChemistryCombinatorial chemistryOrganic chemistryMoleculeBiochemistryHydrogen bondCoenzyme Q – cytochrome c reductaseCytochrome cMitochondrionCrystallography and molecular interactionsCrystallization and Solubility StudiesNonlinear Optical Materials Research