Metal-free enaminone C–N bond cyanation for the stereoselective synthesis of (<i>E</i>)- and (<i>Z</i>)-β-cyano enones
Ting Liu, Jie‐Ping Wan, Yunyun Liu
Abstract
The C–N bond cyanation of tertiary enaminones has been realized for the stereoselective synthesis of both ( E )- and ( Z )-β-cyano enones under mild metal-free conditions, providing highly practical approaches for the synthesis of β-cyano enones.
Topics & Concepts
CyanationStereoselectivityChemistryMetalMedicinal chemistryStereochemistryCombinatorial chemistryOrganic chemistryCatalysisCatalytic C–H Functionalization MethodsSynthesis and Characterization of PyrrolesSynthesis and Catalytic Reactions