Association between Neutrophil Percentage‐to‐Albumin Ratio and All‐Cause Mortality in Critically Ill Patients with Coronary Artery Disease
Tienan Sun, Hua Shen, Qianyun Guo, Jiaqi Yang, Guangyao Zhai, Jingrui Zhang, Biyang Zhang, Yaodong Ding, Chenghui Cai, Yujie Zhou
Abstract
Background . Neutrophil percentage‐to‐albumin ratio (NPAR) has been proved to be associated with clinical outcome of many diseases. This study was aimed at exploring the independent effect of NPAR on all‐cause mortality of critically ill patients with coronary artery disease (CAD). Method . NPAR was calculated as neutrophil percentage numerator divided by serum albumin concentration. Clinical endpoints were 30‐day, 90‐day, and 365‐day all‐cause mortality. Multivariable Cox proportional hazard models were performed to confirm the association between NPAR and all‐cause mortality. Result . 3106 patients with CAD were enrolled. All‐cause mortality rates of 30 days ( P < 0.001), 90 days ( P < 0.001), and 365 days ( P < 0.001) increased as NPAR tertiles increased. And after adjusting for possible confounding variables, NPAR was still independently associated with 30‐day (third tertile group versus first tertile group: HR, 95% CI: 1.924, 1.471‐2.516; P for trend < 0.001), 90‐day (third tertile group versus first tertile group: HR, 95% CI: 2.053, 1.646‐2.560; P for trend < 0.001), and 365‐day (third tertile group versus first tertile group: HR, 95% CI: 2.063, 1.717‐2.480; P for trend < 0.001) all‐cause mortality in patients with CAD. Subgroup analysis did not find obvious interaction in most subgroups. Conclusion . NPAR was independently correlated with 30‐day, 60‐day, and 365‐day all‐cause mortality in critically ill patients with CAD.