Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?
Andrew V. Stachulski, Joshua Taujanskas, Sophie Pate, Rajith K. R. Rajoli, Ghaith Aljayyoussi, Shaun H. Pennington, Stephen A. Ward, W. David Hong, Giancarlo A. Biagini, Andrew Owen, Gemma L. Nixon, Suet C. Leung, Paul M. O’Neill
Abstract
potency of NTZ against SARS-CoV-2 gives further support for drug repurposing with potential in combination chemotherapy approaches. The review concludes with details of second generation thiazolides under development that could lead to improved antiviral therapies for future indications.
Topics & Concepts
NitazoxanideRepurposingDrug repositioningAntiviral drugDrugPotencyMedicineVirologyPharmacologyCoronavirusAtovaquoneAntiparasitic agentDrug developmentBiologyCoronavirus disease 2019 (COVID-19)ImmunologyIn vitroMalariaPlasmodium falciparumInfectious disease (medical specialty)DiseasePathologyEcologyBiochemistryViral Infections and Immunology ResearchTuberculosis Research and EpidemiologyRespiratory viral infections research