Organocatalytic asymmetric synthesis of P-stereogenic molecules
Junyang Liu, Hang Chen, Min Wang, Wangjin He, Jia‐Lei Yan
Abstract
P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems. This review summarizes the key achievements in organocatalytic methodologies for the synthesis of P-stereogenic molecules. Different catalytic systems are emphasized for each strategy class (desymmetrization, kinetic resolution, and dynamic kinetic resolution) with examples cited to illustrate the potential applications of the accessed P-stereogenic organophosphorus compounds.
Topics & Concepts
StereocenterDesymmetrizationKinetic resolutionMoleculeCatalysisChirality (physics)Enantioselective synthesisStereochemistryChemistryOrganocatalysisCombinatorial chemistryOrganic chemistryPhysicsQuarkQuantum mechanicsNambu–Jona-Lasinio modelChiral symmetry breakingOrganophosphorus compounds synthesisAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry Methods