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Regio- and stereoselective C(sp<sup>2</sup>)–H acylation of enamides with aldehydes <i>via</i> transition-metal-free photoredox catalysis

Kai Zhao, Xiao‐Chen Zhang, Ji‐Yu Tao, Xian-Dan Wu, Jia-Xu Wu, Weiming Li, Tong‐Hao Zhu, Teck‐Peng Loh

2020Green Chemistry52 citationsDOI

Abstract

A regio- and stereoselective β-C(sp<sup>2</sup>)–H acylation of enamides with aldehydes is demonstrated, affording geometrically defined acylated enamides under environmentally friendly conditions.

Topics & Concepts

StereoselectivityAcylationChemistryCatalysisTransition metalRegioselectivityOrganic chemistryMedicinal chemistryStereochemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions
Regio- and stereoselective C(sp<sup>2</sup>)–H acylation of enamides with aldehydes <i>via</i> transition-metal-free photoredox catalysis | Litcius