Ruthenium-catalysed C–H/C–N bond activation: facile access to isoindolinones
Xiao‐Qiang Hu, Ye‐Xing Hou, Zi‐Kui Liu, Yang Gao
Abstract
A facile ruthenium-catalysed C–H/C–N bond activation and the subsequent annulation of readily available benzoic acids with <italic>in situ</italic> generated formaldimines are developed for the efficient synthesis of a wide range of biologically important isoindolinones.
Topics & Concepts
ChemistryRutheniumAnnulationBenzoic acidCombinatorial chemistryCatalysisMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and pharmacology of benzodiazepine derivativesSynthetic Organic Chemistry Methods