Neurodevelopmental Correlates of Brain Magnetic Resonance Imaging Abnormalities in Extremely Low-birth-weight Infants
Silvia Martini, Jacopo Lenzi, Vittoria Paoletti, Monica Maffei, Francesco Toni, Anna Fetta, Arianna Aceti, Duccio Maria Cordelli, Mariagrazia Zuccarini, Annalisa Guarini, Alessandra Sansavini, Luigi Corvaglia
Abstract
ObjectiveTo evaluate the relationship between impaired brain growth and structural brain abnormalities at term-equivalent age (TEA) and neurodevelopment in extremely low-birth-weight (ELBW) infants over the first 2 years.MethodsELBW infants born from 2009 through 2018 and undergoing brain magnetic resonance imaging (MRI) at TEA were enrolled in this retrospective cohort study. MRI scans were reviewed using a validated quali-quantitative score, including several white and gray matter items. Neurodevelopment was assessed at 6, 12, 18, and 24 months using the Griffiths scales. The independent associations between MRI subscores and the trajectories of general and specific neurodevelopmental functions were analyzed by generalized estimating equations.ResultsOne hundred-nine ELBW infants were included. White matter volume reduction and delayed myelination were associated with worse general development (b = −2.33, P = .040; b = −6.88, P = .049 respectively), social skills (b = −3.13, P = .019; b = −4.79, P = .049), and eye-hand coordination (b = −3.48, P = .009; b = −7.21, P = .045). Cystic white matter lesions were associated with poorer motor outcomes (b = −4.99, P = .027), while white matter signal abnormalities and corpus callosum thinning were associated with worse nonverbal cognitive performances (b = −6.42, P = .010; b = −6.72, P = .021, respectively). Deep gray matter volume reduction correlated with worse developmental trajectories.ConclusionsDistinctive MRI abnormalities correlate with specific later developmental skills. This finding may suggest that TEA brain MRI may assist with neurodevelopmental prediction, counseling of families, and development of targeted supportive interventions to improve neurodevelopment in ELBW neonates. To evaluate the relationship between impaired brain growth and structural brain abnormalities at term-equivalent age (TEA) and neurodevelopment in extremely low-birth-weight (ELBW) infants over the first 2 years. ELBW infants born from 2009 through 2018 and undergoing brain magnetic resonance imaging (MRI) at TEA were enrolled in this retrospective cohort study. MRI scans were reviewed using a validated quali-quantitative score, including several white and gray matter items. Neurodevelopment was assessed at 6, 12, 18, and 24 months using the Griffiths scales. The independent associations between MRI subscores and the trajectories of general and specific neurodevelopmental functions were analyzed by generalized estimating equations. One hundred-nine ELBW infants were included. White matter volume reduction and delayed myelination were associated with worse general development (b = −2.33, P = .040; b = −6.88, P = .049 respectively), social skills (b = −3.13, P = .019; b = −4.79, P = .049), and eye-hand coordination (b = −3.48, P = .009; b = −7.21, P = .045). Cystic white matter lesions were associated with poorer motor outcomes (b = −4.99, P = .027), while white matter signal abnormalities and corpus callosum thinning were associated with worse nonverbal cognitive performances (b = −6.42, P = .010; b = −6.72, P = .021, respectively). Deep gray matter volume reduction correlated with worse developmental trajectories. Distinctive MRI abnormalities correlate with specific later developmental skills. This finding may suggest that TEA brain MRI may assist with neurodevelopmental prediction, counseling of families, and development of targeted supportive interventions to improve neurodevelopment in ELBW neonates.