C(sp<sup>3</sup>)-Arylation by Conformationally Accelerated Intramolecular Nucleophilic Aromatic Substitution (S<sub>N</sub>Ar)
Steven M. Wales, Rakesh K. Saunthwal, Jonathan Clayden
Abstract
)-arylation. More broadly, our results highlight the power of conformational activation to achieve unprecedented reactivity in the construction of challenging C-C bonds.
Topics & Concepts
Intramolecular forceNucleophilic aromatic substitutionNucleophilic substitutionSubstitution (logic)ChemistryRadical-nucleophilic aromatic substitutionElectrophilic aromatic substitutionAromaticityMedicinal chemistrySubstitution reactionStereochemistryComputational chemistryOrganic chemistryMoleculeComputer scienceProgramming languageCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsCoordination Chemistry and Organometallics