PLGA–collagen–BPNS Bifunctional composite mesh for photothermal therapy of melanoma and skin tissue engineering
Linawati Sutrisno, Huajian Chen, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Abstract
. The PLGA-collagen-BPNS composite mesh had high mechanical strength for easy handling. The PLGA-collagen-BPNS composite mesh facilitated the proliferation of fibroblasts, promoted the expression of angiogenesis-related genes and the genes of components of the extracellular matrix for skin tissue regeneration. The high mechanical strength, photothermal ablation capability and skin tissue regeneration effects demonstrate that the bifunctional PLGA-collagen-BPNS composite mesh is a versatile and effective platform for the treatment of melanoma and the regeneration of skin defects.
Topics & Concepts
BifunctionalMaterials sciencePLGAPhotothermal therapyComposite numberTissue engineeringBiomedical engineeringComposite materialNanotechnologyChemical engineeringMedicineChemistryOrganic chemistryNanoparticleEngineeringCatalysisCorneal Surgery and TreatmentsSilk-based biomaterials and applicationsElectrospun Nanofibers in Biomedical Applications