Highly stereoselective synthesis of polysubstituted housanes and spiro-oxa-housanes: application and mechanistic insights
Abdur Rouf Samim Mondal, Nakul Abhay Bapat, Harshita Mishra, Durga Prasad Hari
Abstract
a strain-release driven diastereospecific 1,2-ester migration that allows the rapid synthesis of functionalized bicyclic imides further highlighted the synthetic utility of the current protocol. Combined experimental studies and computational investigations revealed the origin of the reactivity and stereoselectivity.
Topics & Concepts
StereoselectivityChemistryCombinatorial chemistryStereochemistryOrganic chemistryCatalysisCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques