Inhibiting Iron Mobilization from Bacterioferritin in <i>Pseudomonas aeruginosa</i> Impairs Biofilm Formation Irrespective of Environmental Iron Availability
Anabel Soldano, Huili Yao, Josephine R. Chandler, Mario Rivera
Abstract
would impair biofilm development. Our results show that planktonic and biofilm-embedded cells where the BfrB-Bfd complex is blocked exhibit cytosolic iron deficiency, and poorly developed biofilms, even in iron-sufficient culture conditions. These results underscore inhibition of the BfrB-Bfd complex as a rational target to dysregulate iron homeostasis and possibly control biofilms.
Topics & Concepts
BiofilmChemistryFerredoxinBacteriaMicrobiologyBiochemistryPseudomonas aeruginosaCytosolBiologyEnzymeGeneticsBacterial biofilms and quorum sensingMicrobial Fuel Cells and BioremediationMetal Extraction and Bioleaching