Identifying novel mechanisms of per- and polyfluoroalkyl substance-induced hepatotoxicity using FRG humanized mice
Dakota R. Robarts, Diego Paine‐Cabrera, Manasi Kotulkar, Kaitlyn K. Venneman, Sumedha Gunewardena, Lander Foquet, Greg Bial, Udayan Apte
Topics & Concepts
Perfluorooctanoic acidHepatocyteCYP27A1ChemistrySteatosisPregnane X receptorPerfluorooctaneNonalcoholic fatty liver diseaseNuclear receptorPharmacologyFatty liverBiochemistryInternal medicineEndocrinologyBiologyCholesterolGeneMedicineIn vitroDiseaseOrganic chemistrySodiumSulfonateTranscription factorPer- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactBirth, Development, and Health