Significance of gut microbiota in alcoholic and non-alcoholic fatty liver diseases
Satya Priya Sharma, Ki Tae Suk, Dong Joon Kim
Abstract
Liver-gut communication is vital in fatty liver diseases, and gut microbes are the key regulators in maintaining liver homeostasis. Chronic alcohol abuse and persistent overnutrition create dysbiosis in gut ecology, which can contribute to fatty liver disease. In this review, we discuss the gut microbial compositional changes that occur in alcoholic and nonalcoholic fatty liver diseases and how this gut microbial dysbiosis and its metabolic products are involved in fatty liver disease pathophysiology. We also summarize the new approaches related to gut microbes that might help in the diagnosis and treatment of fatty liver disease.
Topics & Concepts
Fatty liverGut floraDysbiosisAlcoholic liver diseaseNonalcoholic fatty liver diseaseOvernutritionBiologyAlcoholic fatty liverAlcoholic hepatitisLiver diseaseLiver injuryDiseaseMedicinePhysiologyImmunologyInternal medicineEndocrinologyObesityCirrhosisGut microbiota and healthLiver Disease Diagnosis and TreatmentDiet and metabolism studies