<i>In vitro</i> anticancer activity of parent and nano-encapsulated samarium(<scp>iii</scp>) complex towards antimicrobial activity studies and FS-DNA/BSA binding affinity
Saeid Asadpour, Zahra Aramesh‐Boroujeni, Shohreh Jahani
Abstract
, showing relatively a high tendency of the Sm complex to DNA and BSA. Besides, the Sm complex was docked to BSA and DNA by the autodock program. The results of the docking calculations were in good agreement with the experimental examinations. Additionally, the antifungal and antibacterial properties of this complex were investigated. The anticancer tests on the effect of the Sm complex, starch nano-encapsulation, and lipid nano-encapsulation in MCF-7 and A-549 cell lines were performed by the MTT method. It can be observed that the Sm complex and its nanocarriers presented a selective inhibitory effect on various cancer cell growths.
Topics & Concepts
SamariumIn vitroChemistryAntimicrobialDNACombinatorial chemistryNuclear chemistryBiochemistryOrganic chemistryMetal complexes synthesis and propertiesComputational Drug Discovery MethodsSynthesis and Characterization of Heterocyclic Compounds