Vinyl sulfone-based inhibitors of trypanosomal cysteine protease rhodesain with improved antitrypanosomal activities
Huaisheng Zhang, Jasmine T. Collins, Rogers Nyamwihura, Olamide Crown, Oluwatomi Ajayi, Ifedayo Victor Ogungbe
Topics & Concepts
Trypanosoma bruceiQuinolineTrypanocidal agentChemistryCysteine proteaseSulfoneCysteineProteaseAfrican trypanosomiasisADMEBiochemistryEnzymeTrypanosomaEnzyme inhibitorPharmacologyTrypanosomiasisIn vitroBiologyVirologyOrganic chemistryGeneTrypanosoma species research and implicationsResearch on Leishmaniasis StudiesSynthesis and Biological Evaluation