Mild and Selective Method of Bromination of Flavonoids
Martina Hurtová, David Biedermann, Marek Kuzma, Vladimı́r Křen
Abstract
A new method was developed for the mild and selective bromination of simple aromatic compounds and flavonoids in good yields using α,β-dibromohydrocinnamic acid in the presence of a base. This procedure enables selective mono- or dibromination of compounds highly sensitive to oxidative or radical attack. New brominated derivatives of silymarin flavonolignans and related flavonoids were prepared. These brominated derivatives can be used as valuable synthetic intermediates in further synthesis.
Topics & Concepts
HalogenationChemistryOrganic chemistryPhenolsCombinatorial chemistrySilymarin and Mushroom PoisoningMedicinal plant effects and applicationsPhenothiazines and Benzothiazines Synthesis and Activities