An investigation of the antileishmanial properties of semi-synthetic saponins
Orlagh H. Anderson, Joseph Beckett, Carla C. Briggs, Liam A. Natrass, Charles F. Cranston, Elizabeth J. Wilkinson, Jack H. Owen, Rhodri Mir Williams, Angelos Loukaidis, Marc E. Bouillon, Deiniol Pritchard, Martina Lahmann, Mark S. Baird, Paul W. Denny
Abstract
amastigotes, the mammalian pathogenic form. One of these, hederagenin disuccinate, was sufficiently non-toxic to the macrophage host cell to facilitate further analyses, selectivity index (SI) > 10. Whilst this was not active in an infected cell model, the anti-leishmanial properties of hederagenin-derivatives have been demonstrated, and the possibility of improving the selectivity of natural hederagenin through chemical modification has been established.
Topics & Concepts
Traditional medicineChemistryMedicineResearch on Leishmaniasis StudiesToxin Mechanisms and ImmunotoxinsPharmacological Effects of Natural Compounds