Design, synthesis, and evaluation of novel benzofuran and pyrazole-based derivatives as dual AChE/BuChE inhibitors with antioxidant properties for Alzheimer's disease management
Mahmoud S. Elkotamy, Mohamed K. Elgohary, Mahmoud Abdelrahman Alkabbani, Mohamed M Hefina, Haytham O. Tawfik, Mohamed Farès, Wagdy M. Eldehna, Hatem A. Abdel‐Aziz
Topics & Concepts
BenzofuranChemistryPyrazoleDonepezilAntioxidantAcetylcholinesteraseCombinatorial chemistryStereochemistryEnzymeBiochemistryDiseaseDementiaMedicinePathologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity