The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization
Anna Schorcht, Christopher A. Cottrell, Pavel Pugach, Rajesh P. Ringe, Alvin X. Han, Joel D. Allen, Tom L.G.M. van den Kerkhof, Gemma E. Seabright, Edith E. Schermer, Thomas J. Ketas, Judith A. Burger, Jelle van Schooten, Celia C. LaBranche, Gabriel Ozorowski, Natalia de Val, Daniel Bader, Hanneke Schuitemaker, Colin A. Russell, David C. Montefiori, Marit J. van Gils, Max Crispin, Per Johan Klasse, Andrew B. Ward, John P. Moore, Rogier W. Sanders
Abstract
Forty years after the first description of HIV-1, the search for a protective vaccine is still ongoing. The sole target for antibodies that can neutralize the virus are the trimeric envelope glycoproteins (Envs) located on the viral surface.
Topics & Concepts
GlycanGlycoproteinNeutralizationAntibodyBiologyTrimerVirologyGlycosylationHIV vaccineNeutralizing antibodyGp41Immune systemCell biologyVirusImmunologyMolecular biologyChemistryBiochemistryEpitopeVaccine trialDimerOrganic chemistryHIV Research and TreatmentGlycosylation and Glycoproteins ResearchCytomegalovirus and herpesvirus research