Selective postnatal excitation of neocortical pyramidal neurons results in distinctive behavioral and circuit deficits in adulthood
William E. Medendorp, Andreas Björefeldt, Emmanuel L. Crespo, Mansi Prakash, Akash Pal, Madison L. Waddell, Christopher I. Moore, Ute Hochgeschwender
Abstract
optogenetic interrogation in adults revealed decreased baseline but increased stimulus-evoked firing rates of pyramidal neurons and impaired recruitment of inhibitory neurons. Slice recordings in adults from prefrontal cortex layer 5 pyramidal neurons revealed decreased intrinsic excitability and increased synaptic E/I ratio. Together these results support the prediction that enhanced pyramidal firing during development, in otherwise normal cortex, can selectively drive altered adult circuit function and maladaptive changes in behavior.
Topics & Concepts
NeuroscienceOptogeneticsParvalbuminNeocortexPrefrontal cortexInhibitory postsynaptic potentialExcitatory postsynaptic potentialStimulus (psychology)Biological neural networkPsychologyPremovement neuronal activityBiologyCognitionPsychotherapistNeuroscience and Neuropharmacology ResearchMemory and Neural MechanismsPhotoreceptor and optogenetics research