Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands
Sarah‐Jane Richards, Tessa Keenan, Jean-Baptiste Vendeville, David E. Wheatley, Harriet S. Chidwick, Darshita Budhadev, Claire E. Council, Claire S. Webster, Hélène Ledru, Alexander N. Baker, Marc Walker, M. Carmen Galán, Bruno Linclau, Martin A. Fascione, Matthew I. Gibson
Abstract
which are shown to tolerate fluorinated glycans, introducing structural diversity which would be very laborious by chemical methods alone. These results demonstrate that integrating non-natural, fluorinated glycans into nanomaterials can encode unprecedented selectivity with potential applications in biosensing.
Topics & Concepts
GalectinSelectivityGlycanChemistryNanoparticleCombinatorial chemistryGalectin-1NanotechnologyBiochemistryMaterials scienceCell biologyCatalysisGlycoproteinBiologyGalectins and Cancer BiologyGlycosylation and Glycoproteins ResearchPeptidase Inhibition and Analysis